α-Synuclein and Lewy pathology in Parkinson's disease.
Identifieur interne : 000468 ( Main/Exploration ); précédent : 000467; suivant : 000469α-Synuclein and Lewy pathology in Parkinson's disease.
Auteurs : Lorraine V. Kalia [Canada] ; Suneil K. KaliaSource :
- Current opinion in neurology [ 1473-6551 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : alpha-Synuclein.
- metabolism : Brain, Neurons, Parkinson Disease.
- pathology : Brain, Lewy Bodies, Neurons, Parkinson Disease.
- Humans.
Abstract
The role of protein aggregates, such as Lewy body inclusions, in the molecular pathogenesis of Parkinson's disease has remained controversial and elusive. The protein α-synuclein is a major component of these inclusions but it can exist in many alternate conformations. Here we review advances in our understanding of the roles of Lewy pathology and α-synuclein in Parkinson's disease.
DOI: 10.1097/WCO.0000000000000215
PubMed: 26110807
Affiliations:
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Le document en format XML
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Kalia</name><affiliation wicri:level="1"><nlm:affiliation>aDivision of Neurology, Department of Medicine bDivision of Neurosurgery, Department of Surgery cTanz Centre for Research in Neurodegenerative Diseases, University of Toronto dMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Department of Medicine eToronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>aDivision of Neurology, Department of Medicine bDivision of Neurosurgery, Department of Surgery cTanz Centre for Research in Neurodegenerative Diseases, University of Toronto dMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Department of Medicine eToronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K" last="Kalia">Suneil K. Kalia</name></author></analytic><series><title level="j">Current opinion in neurology</title><idno type="eISSN">1473-6551</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Humans</term><term>Lewy Bodies (pathology)</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Lewy Bodies</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of protein aggregates, such as Lewy body inclusions, in the molecular pathogenesis of Parkinson's disease has remained controversial and elusive. The protein α-synuclein is a major component of these inclusions but it can exist in many alternate conformations. Here we review advances in our understanding of the roles of Lewy pathology and α-synuclein in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K" last="Kalia">Suneil K. Kalia</name></noCountry><country name="Canada"><noRegion><name sortKey="Kalia, Lorraine V" sort="Kalia, Lorraine V" uniqKey="Kalia L" first="Lorraine V" last="Kalia">Lorraine V. Kalia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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